Chapter 06Interventions

The hormone cycle and its stop points

Hormones feed each other in a loop, so a problem in one spreads to the rest. Each stop is a place where the loop can be interrupted.

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Fig. 06 · One loop, six stops Tap a stop to interrupt the loop
one loop, six places to interrupt it Sleep Insulin resistance Cortisol Mood · cognition Estrogen Melatonin 1 2 3 4 5 6
The loop is running
Optimal06 · Interventions

One loop

Sleep, insulin, cortisol, mood, estrogen and melatonin feed each other in a loop, so a problem in one spreads to the rest.

The moving dot is that effect travelling around the ring.

Stop 1

Sleep

DaridorexantLemborexant (Dayvigo)DoxepinGlycineAshwagandhaProgesteroneLifestyle
Stop 2

Insulin resistance

MetforminGLP-1 agonists
Stop 3

Cortisol

DHEAOmega-3RhodiolaMagnesium and B6AshwagandhaCircadian rhythmExerciseLifestyle
Stop 4

Mood, fatigue, cognition

SSRI (escitalopram)Benzodiazepine (alprazolam)Creatine 5 g/day
Stop 5

Estrogen

Progesterone
Stop 6

Melatonin

Light exposureTryptophanB6FolateMagnesiumExerciseTemperature

Six places to interrupt it

Each stop on the ring is a place where the loop can be interrupted, with the tools most often used there. Tap any stop on the ring to revisit it.

Medication names are for discussion with your provider, not a recommendation.